Dr. Michalowski's domain of expertise is Artificial Intelligence (AI) with research interests spanning several AI areas of particular importance to medical informatics including data integration, data modeling, machine learning, clinical decision support, and knowledge representation. Automated reasoning, including constraint-based approaches, data analytics using spatio-temporal analysis methods, planning and scheduling, and Bayesian-based machine learning for game playing, rounds out his research background.

His research philosophy in the area of medical informatics is centered on interdisciplinarity and brings advanced AI methods and approaches to clinical decision support, including the mitigation of computerized clinical practice guidelines for complex patients, and personalized medicine. Methodologically, Dr. Michalowski uses automated reasoning to provide clinicians and nurses with decision support at the point of care. He also applies problem modeling techniques to capture knowledge required for improving treatment decisions and uses big data analytics to support personalized medicine. He is also involved in the development of mobile educational tools for educators and students where he uses integrated automated reasoning, knowledge representation using ontologies, and human factors design.