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The CECAD research group led by Prof. Dr. Martin Krönke explores the lipid composition of cell membranes and its alterations in the aging organism. A reduction in the concentration of specific enzymes of sphingolipid metabolism, ceramide synthases-1 and -5, results in changes in the lipid composition in membranes, leading to myopathy of skeletal muscles. In humans, this is associated with frailty of elderly people and of patients suffering chronic critical diseases. One other isoform of the family of ceramide synthases, ceramide synthase-4, has been shown to be involved in the regulation of the hair follicle cycle. Down-regulation of ceramide synthase-4 leads to age-dependent hair loss. The precise mechanisms of action of both ceramide synthase-1,-5, and -4 have not yet been explored. The group’s findings will break new ground in the understanding of the impact of age-dependent changes of sphingolipid concentrations in cell membranes and open avenues for novel therapies, especially for older patients.
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Sonja Mertins,Paul G Higgins,Caroline Thunissen, Henri Magein,Quentin Gilleman,Pascal Mertens,María González Rodríguez, Liza Marie Maus,Harald Seifert,Martin Krönke,Alexander Klimka
JOURNAL OF MEDICAL MICROBIOLOGYno. 4 (2023)
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Alexander Klimka, Sonja Mertins, Anne Kristin Nicolai, Liza Marie Rummler,Paul G. Higgins,Saskia Diana Günther,Bettina Tosetti,Oleg Krut,Martin Krönke
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