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The primary research interest of the Blackledge group is the study of protein dynamics by NMR, often combined with complementary biophysical techniques and advanced molecular simulation, to characterize the role of conformational flexibility in biological function on a broad range of time and length scales, from molecular recognition dynamics in folded proteins, to reorganizational dynamics of large multi-domain assemblies exhibiting extensive protein disorder to the study of fundamental biophysics underlying protein dynamics. Most recently he uses these techniques to describe the conformational space sampled by highly flexible or intrinsically disordered proteins, to map their interaction trajectories at atomic resolution, and to determine the relationship between dynamic behaviour and functional mechanism. Amongst other applications these methods are applied to understand the function of highly dynamic proteins involved in viral replication, molecular signalling and neurodegenerative disease.
Research Interests
Papers共 336 篇Author StatisticsCo-AuthorSimilar Experts
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Duc-Duy Vu,Alessio Bonucci, Manon Brenière,Metztli Cisneros-Aguirre,Philippe Pelupessy, Ziqing Wang,Ludovic Carlier,Guillaume Bouvignies,Patricia Cortes,Aneel K Aggarwal,Martin Blackledge,Zoher Gueroui,
Nature structural & molecular biologypp.1-13, (2024)
crossref(2024)
Frontiers in immunology (2024): 1419165-1419165
Maiia Botova,Aldo R. Camacho-Zarco, Jacqueline Tognetti,Luiza Mamigonian Bessa,Serafima Guseva, Emmi Mikkola,Nicola Salvi,Damien Maurin, Torsten Herrmann,Martin Blackledge
biorxiv(2024)
Raghavendar R. Sanganna Gari,Grigory Tagiltsev,Ruth A. Pumroy,Yining Jiang,Martin Blackledge,Vera Y. Moiseenkova-Bell,Simon Scheuring
Communications biologyno. 1 (2023): 966-10
PNAS NEXUSno. 1 (2023): pgae006-pgae006
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
bioRxiv : the preprint server for biology (2023)
biorxiv(2023)
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