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Dr Schneider is an internationally known leader in skeletal muscle excitation-contraction coupling, the series of steps whereby electrical depolarization of the normally inside negative muscle membrane potential initiates release of calcium ions (Ca2+) from their intracellular storage location, the muscle sarcoplasmic reticulum (SR), allowing Ca2+ ions bind to regulatory sites on muscle contractile filaments, which serves as a switch to permit contractile filament interaction, producing force development and muscle shortening. In pioneering work in collaboration with his post doc mentor Dr W.K. Chandler (Yale University), Dr Schneider made the first measurements of tiny electrical currents (charge displacement currents or channel “gating” currents) due to the redistribution of charged voltage sensor proteins within the muscle membrane. Such gating currents were previously predicted in the classic studies of Hodgkin and Huxley on voltage dependent channel activation underlying the action potential in nerve axons, and were first detected in any excitable cell membrane by Schneider and Chandler in skeletal muscle, where they control Ca2+ release from Ca2+ release channels in the spatially immediately adjacent SR membrane. Analogous gating currents were subsequently identified by other groups for gating voltage dependent Na+, K+ and Ca2+ channels in other excitable cells.
Research Interests
Papers共 403 篇Author StatisticsCo-AuthorSimilar Experts
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Naita M. Wirsik, Pia C. Appel, Alexander Braun,Moritz J. Strowitzki,Nikolai Schleussner,Henrik Nienhüser,Martin Schneider,Thomas Schmidt
Journal of Surgical Research (2024): 176-184
JOURNAL OF CLINICAL ANESTHESIA (2024): 111495-111495
Elaine M. Glenny,Tengda Lin, Victoria M. Bandera,Biljana Gigic,Aik Choon Tan,Babak Mirminachi, Saratchandra S. Khumukcham, Alessandro Carpanese,Christy A. Warby, Olena Aksonova,Caroline Himbert,Jennifer Ose,
Cancer Researchno. 6_Supplement (2024): 2190-2190
biorxiv(2024)
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancerno. 5 (2024): 298-298
Tolga Lokumcu,Murat Iskar,Martin Schneider,Dominic Helm,Glynis Klinke,Lisa Schlicker,Frederic Bethke, Gabriele Mu''ller,Karsten Richter,Gernot Poschet,Emma Phillips,Violaine Goidts
ACS NANOno. 3 (2024): 2500-2519
Naita Maren Wirsik, Mingyi Chen, Liping He, Uraz Yasar, Justus Gaukel,Alexander Quaas,Henrik Nienhueser, Ella Leugner, Shuai Yuan,Nikolai Schleussner,Jin-On Jung, Jadie Sue Pluecker,
Vukasin M Jovanovic, Narisu,Lori L Bonnycastle, Ravi Tharakan, Kendall T Mesch,Hannah J Glover,Tingfen Yan,Neelam Sinha,Chaitali Sen, David Castellano, Shu Yang, Dvir Blivis,
biorxiv(2024)
Victoria M. Bandera,Tengda Lin,Caroline Himbert,Elaine M. Glenny,Aik Choon Tan,Jennifer Ose,Christy Warby, Olena Aksonova, Alessandro Carpanese,Chris Stubben,David Nix,Kenneth Boucher,
Cancer Researchno. 6_Supplement (2024): 3406-3406
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Author Statistics
#Papers: 403
#Citation: 11804
H-Index: 52
G-Index: 95
Sociability: 8
Diversity: 4
Activity: 259
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