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Bio
Since 2000, my group aims to uncover the molecular basis of pathogenicity of the plant-pathogenic fungus Fusarium oxysporum, a fungus that causes wilt disease or root/bulb-rot in many plant species of agricultural and horticultural importance.
Current research includes the identification and charaterization of genes required for pathogenicity, especially those that encode effectors : proteins secreted during colonization of host plants. These effectors are often required for full virulence towards a specific host plant. Some, however, are recognized in resistant plants carrying a matching Resistance gene , in which case they are (also) referred to as avirulence factors. Expression of effector genes is highly upregulated during plant (root) colonization, and we are studying the molecular mechanisms underlying this induction of expression.
In F. oxysporum, effector genes reside in pathogenicity chromosomes. These chromosomes are transposon-rich, can transfer between clonal lines and appear to evolve faster than the 'core' genome. This discovery led us to study molecular mechanisms underlying genome evolution in relation to host-specific pathogenicity.
Research Interests
Papers共 161 篇Author StatisticsCo-AuthorSimilar Experts
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Frontiers in plant science (2024): 1384431-1384431
Thomas R. Aalders,Mara de Sain,Fleur Gawehns, Nina Oudejans, Yoran D. Jak,Henk L. Dekker,Martijn Rep,Harrold A. van den Burg,Frank L. W. Takken
PLANT BIOTECHNOLOGY JOURNALno. 1 (2024): 248-261
Misha Paauw, Willem E.W. Schravesande, Nanne W. Taks,Martijn Rep,Sebastian Pfeilmeier, Harrold Alfred van den Burg
crossref(2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 30 (2023)
MOLECULAR PLANT PATHOLOGY (2023)
FRONTIERS IN PLANT SCIENCE (2023): 1123403-1123403
Proceedings of the National Academy of Sciences of the United States of Americano. 30 (2023)
Molecular Plant Pathologyno. 8 (2023): 914-931
Journal of fungi (Basel, Switzerland)no. 4 (2023): 486-486
biorxiv(2022)
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