基本信息
浏览量:8
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Dr. Stipanuk's professional career focused on the study of amino acid metabolism, particularly the metabolism of the sulfur-containing amino acid cysteine. Her work has contributed to an understanding of the intermediary pathways of cysteine metabolism in mammalian cells and of the role of various tissues in cysteine metabolism, including glutathione synthesis and taurine production, within the whole body. The Stipanuk laboratory played a major role in elucidating the physiological function, regulation, structure, and protein coenzyme formation of cysteine dioxygenase, an iron-dependent enzyme that catalyzes the first step in the cysteinesulfinate-dependent pathway of cysteine catabolism. Cysteine dioxygenase plays a crucial role in regulating cysteine levels, in promoting taurine biosynthesis, and in restricting the metabolism of cysteine through the intermediate hydrogen sulfide, preventing sulfide toxicity and facilitating hydrogen sulfide signaling. The regulation of cysteine dioxygenase abundance and activity state occurs specifically in response to cysteine levels. The Stipanuk laboratory was also interested in elucidating the mechanism(s) by which the concentrations of other amino acids are sensed by cells and how cells respond to changes in amino acid availability.
研究兴趣
论文共 139 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
J Krijt,J Sokolová,J Šilhavý,P Mlejnek, J Kubovčiak,F Liška,H Malínská,M Hüttl,I Marková, M Křížková,M H Stipanuk,T Křížek,
Encyclopedia of Inorganic and Bioinorganic Chemistrypp.1-11, (2015)
加载更多
作者统计
#Papers: 139
#Citation: 6813
H-Index: 45
G-Index: 81
Sociability: 5
Diversity: 3
Activity: 4
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn