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Dr. Marsha A. Moses is the Julia Dyckman Andrus Professor at Harvard Medical School and the Director of the Vascular Biology Program at Boston Children's Hospital. She has had a long-standing interest in identifying and characterizing the biochemical and molecular mechanisms that underlie the regulation of tumor growth and progression. Dr. Moses and her laboratory have discovered a number of angiogenesis inhibitors that function at both the transcriptional and translational level, some of which are being developed for clinical use.
Significant efforts are also now underway in the Moses Lab to identify the genes, and the proteins that they encode, that are responsible for the escape from tumor dormancy. This critical checkpoint, during which time a tiny benign, avascular tumor acquires the vascular phenotype, is a prerequisite for subsequent tumor growth and progression. The Moses Lab has recently identified and validated a number of genes which are differentially expressed during the angiogenic switch and is currently developing molecular and biochemical interventions to regulate the switch by targeting some of these genes.
Cited as a pioneer in the exciting new field of biomarker medicine by The Journal of the National Cancer Institute, Dr. Moses established a Proteomics Initiative in her laboratory that has led to the discovery of panels of noninvasive urinary cancer biomarkers that can predict disease status and stage in cancer patients and that are sensitive and specific markers of disease progression and therapeutic efficacy of cancer drugs. A number of these urine tests have been made commercially available.
研究兴趣
论文共 208 篇作者统计合作学者相似作者
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Cancer Researchno. 6_Supplement (2024): 1500-1500
Science Advancesno. 18 (2023)
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Roopali Roy, Elisa Schunkert, Petra Olivova,Martin Gilar, Scott Geromanos, Guo-Zhong Li,John Gebler,Adelle Dagher,Andrew El-Hayek, Rama Aldakhlallah,David Zurakowski,Susan Pories,
CANCER RESEARCHno. 7 (2023): 3433-3433
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Michael N. Lombardo,Roopali Roy,Susan Pories, Meg Lotz, Rama Aldakhlallah,Simon T. Dillon,Towia A. Libermann,Marsha A. Moses
CANCER RESEARCHno. 7 (2023)
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iScienceno. 8 (2023): 107272-107272
Michael N. Lombardo,Roopali Roy,Susan E. Pories, Meg Lotz, Rama Aldakhlallah,Simon T. Dillon,Towia A. Libermann,Marsha A. Moses
Cancer Researchno. 7_Supplement (2023): 5315-5315
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Roopali Roy,Emily Man,Katherine Gonzalez,Lauren Merritt,Cassandra Daisy, Rama Aldakhallah,Liang Sun, Biju Isaac,Shira Rockowitz, Margaret Lotz-Bousvaros,Susan Pories,Marsha A. Moses
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Cancer Researchno. 12 (2022): 2190-2190
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Springer eBookspp.379-400, (2022)
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