基本信息
浏览量:40
职业迁徙
个人简介
1. Regulation of DNA repair after exposure to genotoxic stress
During the life span, cells are exposed to different endogenous and exogenous stress factors. These are also DNA damaging agents such as UV light, ionizing radiation, oxidative stress and chemical mutagens. As self-defending mechanisms within a cell, different DNA repair mechanisms have evolved in order to protect the DNA molecule from mutagenic and toxic effects from such substances.
2. Transcriptional regulation of DNA repair genes
Cells can react on genotoxic stress by up- or down-regulation of particular genes. Proto-oncogenes from the c-fos/c-jun family as well as the tumor suppressor gene p53 are directly induced after DNA damage. The corresponding proteins can further induce other genes to work as transcription factors.
3. DNA repair proteins as resistance markers in chemotherapy
p53: a resistance marker for alkylating agents
p53, Xiap, Survivin, WRN: Resistance-marker for Topoisomerase I inhibitors
MGMT: Resistance-marker for alkylating agents
During the life span, cells are exposed to different endogenous and exogenous stress factors. These are also DNA damaging agents such as UV light, ionizing radiation, oxidative stress and chemical mutagens. As self-defending mechanisms within a cell, different DNA repair mechanisms have evolved in order to protect the DNA molecule from mutagenic and toxic effects from such substances.
2. Transcriptional regulation of DNA repair genes
Cells can react on genotoxic stress by up- or down-regulation of particular genes. Proto-oncogenes from the c-fos/c-jun family as well as the tumor suppressor gene p53 are directly induced after DNA damage. The corresponding proteins can further induce other genes to work as transcription factors.
3. DNA repair proteins as resistance markers in chemotherapy
p53: a resistance marker for alkylating agents
p53, Xiap, Survivin, WRN: Resistance-marker for Topoisomerase I inhibitors
MGMT: Resistance-marker for alkylating agents
研究兴趣
论文共 109 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Oliver Krämer,Al-Hassan Mustafa, Giuseppe Petrosino, Marten Fischer, Luisa Ricciardi,Désirée Gül,Markus Christmann,Helen Morrison, Matthias Wirth
crossref(2024)
ANTICANCER RESEARCHno. 3 (2024): 901-910
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger,Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
International journal of molecular sciencesno. 5 (2023): 4684-4684
Caroline Quarz, Max J. Carlsson,Anastasia S. Vollmer,Teodora Nikolova,Markus Christmann,Thomas Hofmann,Simone Stegmüller,Elke Richling,Alexander Cartus,Jörg Fahrer
Lebensmittelchemieno. S1 (2023)
引用0浏览0引用
0
0
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger, Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
Maja T. Tomicic, Dorthe Aasland, Steffen C. Naumann, Ruth Meise, Christina Barckhausen,Bernd Kaina,Markus Christmann
crossref(2023)
Dorthe Aasland, Laura Götzinger, Laura Hauck, Nancy Berte, Jessica Meyer, Melanie Effenberger,Simon Schneider, Emelie E. Reuber,Wynand P. Roos,Maja T. Tomicic,Bernd Kaina,Markus Christmann
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn