基本信息
浏览量:234
职业迁徙
个人简介
Research Interests:
Receptor function, small molecules, centrosome and associated proteins.
Key words: Receptors, cancer, structure.
Description of Research:
Dr. Greene's research is concerned with defining the principles of receptor function. An area he has concentrated on for the last 19 years involves members of the erbB gene family. Greene's laboratory discovered that pl85c-neu could associate with EGFR to form a heteromeric assembly. This heteromeric complex possessed unique properties including increased kinase activity. The heterodimers had a higher affinity for EGF than homomeric forms of the EGFR receptor and were found to represent the major signaling receptor form. Heteromer formation was found to be preferred over homomeric assembly and the ectodomains were found essential in stabilizing the dimeric species.
Receptor function, small molecules, centrosome and associated proteins.
Key words: Receptors, cancer, structure.
Description of Research:
Dr. Greene's research is concerned with defining the principles of receptor function. An area he has concentrated on for the last 19 years involves members of the erbB gene family. Greene's laboratory discovered that pl85c-neu could associate with EGFR to form a heteromeric assembly. This heteromeric complex possessed unique properties including increased kinase activity. The heterodimers had a higher affinity for EGF than homomeric forms of the EGFR receptor and were found to represent the major signaling receptor form. Heteromer formation was found to be preferred over homomeric assembly and the ectodomains were found essential in stabilizing the dimeric species.
研究兴趣
论文共 666 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2023)
Peeyush N Goel,Hongtao Zhang,Ramachandran Murali,Cai Zheng,Mei Q Ji, Angelica Patterson,Payal Grover,Mark Greene
Biochemical and biophysical research communications (2023): 39-46
Payal Grover,Selene Nunez-Cruz,John Leferovich, Tyra Wentz, Atrish Bagchi,Michael C Milone,Mark I Greene
Biochemical and biophysical research communications (2023): 51-60
Zheng Cai,Khalil Bdeir,Serge Yarovoi,Lubica Rauova,Gowthami M. Arepally,Sanjay Khandelwal, Jerome Rollin, Yves Gruel, Sergei Zaitsev,Mortimer Poncz,Mark I. Greene,Douglas B. Cines
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn