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Bio
I am a medical microbiologist who has worked for many years in the area of infections of medical devices. My laboratory focuses on development of novel antimicrobials that have applications as antibiotics and disinfectants. We also develop new antimicrobial coatings that can be used for a variety of purposes, including coating of medical devices to reduce associated infections. We have taken several of these through to pre-clinical testing, and antimicrobial contact lenses through to Phase III clinical trials. Within the area of contact lens research, we focus on understanding the aetiology of adverse events and comfort during contact lens wear. Our research includes adhesion and biofilm formation of ocular pathogenic microbes (most notably Pseudomonas aeruginosa and Staphylococcus aureus). This research involves the study of microbial pathogenesis, and mammalian tissue responses to microbes and biomaterials. We have established several animal and cell-based models for studying contact lens adverse events and biomaterial infections. Our research has also encompassed proteomic and lipidomic studies of the tear film and its interaction with contact lenses. We have applied new techniques that allow the quantification individual proteins and lipids that adsorb onto contact lenses, or are biomarkers for changes to the ocular surface. This allows researchers, for the first time, to be able to assess the contribution of particular proteins or lipids to the production of adverse responses during lens wear. We have also investigated the use of tears as the source of biomarkers for diabetes, breast and prostate cancer. These research studies have led to the publication of 15 patents and over 450 peer reviewed papers.
Research Interests
Papers共 631 篇Author StatisticsCo-AuthorSimilar Experts
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Furqan A. Maulvi, Miralba B. Parmar,Kiran H. Shetty, Ashmi R. Patel,Bhargavi V. Desai,Bhavin A. Vyas,Ditixa T. Desai,Parthasarathi Kalaiselvan,Simin Masoudi,Dinesh O. Shah,Mark D. P. Willcox
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2024): 133550
Contact Lens and Anterior Eyeno. 3 (2024): 102154-102154
Hetal P. Patel, Priyanka J. Patel, Bhargavi Desai,Rikin Patel,Ditixa T. Desai,Bhavin A. Vyas,Mark D. P. Willcox,Furqan A. Maulvi
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2024): 133786
Journal of peptide science : an official publication of the European Peptide Societyno. 6 (2024): e3560-e3560
PLOS NEGLECTED TROPICAL DISEASESno. 1 (2024): e0011878-e0011878
PLOS ONEno. 2 (2024): e0298449-e0298449
Frontiers in Medicine (2024): 1348463-1348463
Heba Alenezi,Grant Parnell,Stephen Schibeci,Jerome Ozkan,Mark Willcox, Andrew J R White,Nicole Carnt
Frontiers in cellular and infection microbiology (2024): 1346821-1346821
Contact lens & anterior eye : the journal of the British Contact Lens Associationpp.102246-102246, (2024)
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