I am a computational biologist specialising in the analysis of genomics data to improve health outcomes in children with cancer, at the interface of diagnostics and discovery research.
My multi-disciplinary group develops novel computational approaches to make sense of genomics, transcriptomics and clinical data, predominantly applied to childhood cancer, but with lots of experience in other cancers and patients with rare genetic diseases. Much of this research is focused on developing tools to identify, understand and interpret mutations in patients, including complex, noncoding and atypical splice-altering genetic variants, which are commonly overlooked drivers of disease. By collaborating widely with clinicians and fundamental biologists, my team seeks to identify answers for patients today and make a long-term impact on our understanding of the molecular basis of disease. My team also develops the digital research architecture that underpins the Zero Childhood Cancer Program, an ambitious national research program that uses precision medicine to diagnose and treat Australian children with cancer.