His research focused on Natural Killer cell receptor expression and function on T lymphocytes. He undertook postdoctoral training with Prof. Dimitris Kioussis at the National Institute of Medical Research, London, investigating mechanisms leading to lymph node and thymus formation and function.
In 2006 he moved as a lecturer to the Centre for Immunology and Infection at the University of York focusing on stromal immunology to identify stromal cell formation and function in human and murine lymph nodes and tertiary lymphoid tissue using fluorescent lineage reporters. In 2007 he initiated an on-going collaboration with Prof. Jonathan Timmis in the Electronics Department to apply computational and mathematical modelling to understand immune function. He founded and co-directed the York Computational Immunology Laboratory. Through this work he has been a passionate advocate for novel 3Rs based approaches in immunology. In 2016 he was promoted to Professor of Immunology with a joint appointment in the Department of Biology and Hull York Medical School.