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Bio
In March 2005 I obtained my PhD degree within the Department of Pathology, Cardiovascular Research Institute Maastricht Maastricht University. From Dec. 2004-Dec. 2006 I studied downstream modulators of CD40/CD40L in atherosclerosis as a post-doctoral fellow at the Department of Pathology, Maastricht University. During this period, I received a travel grant from the Netherlands Heart Foundation to visit the lab of Dr. R. Stan at Dartmouth University in the USA to gain expertise in lipid raft isolation. In this project I focused on trafficking and downstream CD40 signaling using lipid raft isolation, yeast-two-hybrid screening and CD40-TRAF transgenic mice. TRAF6 was shown to be the key regulator of CD40 signaling in neointima formation (Blood 2008). From Dec. 2006-Sept. 2009 I studied VEGFR signaling as a post-doctoral fellow at the Department of Cardiology, Maastricht University (6th Framework program EU grant nr. 504743). From a Yeast-two hybrid screening, I identified the metalloprotease ADAM10 as novel binding partner of VEGFR2.
In 2007 I received a prestigious personal grant from the Netherlands Heart Foundation (Dr. E. Dekker grant nr. 2007T034, 250k€) to further unravel the role of ADAM10 in VEGF(R) mediated endothelial cell functions, angiogenesis and atherosclerosis. ADAM10 was shown to be expressed in human atherosclerotic plaques, associated with plaque angiogenesis and increased during plaque progression. Furthermore VEGF was shown to induce ADAM10 activity, which is required for shedding of the endothelial adhesion molecule VE-cadherin, endothelial cell migration and angiogenesis in vitro (ATVB 2010). In Sept. 2009, I continued this project within the Department of Molecular Genetics, Maastricht University, particularly focussing on ADAM10 and ADAM17 activities in macrophage functions and atherosclerosis. Development of my research group was further supported by another personal grant from the Netherlands Heart Foundation (Dr. E. Dekker grant nr. 2012T079, 355k€) and a grant from CARIM (180k€) to study the effects of HDL on macrophage inflammatory responses. From Okt. 2013, I am appointed as Assistant Professor within the Department of Pathology, Maastricht University. Regarding my recent exciting data on HDL’s contrasting cell-specific effects in inflammation, partly depending on ADAMs (published in Cell Metabolism 2017), I have extended my research line by studying the role of ADAMs and HDL in vascular inflammation.
Research Interests
Papers共 85 篇Author StatisticsCo-AuthorSimilar Experts
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EUROPEAN JOURNAL OF IMMUNOLOGYno. 1 (2024): e2350464-e2350464
Han Jin, Cheng Zhang,Jan Nagenborg,Peter Juhasz,Adele V. Ruder, Cornelis J. J. M. Sikkink,Barend M. E. Mees,Olivia Waring,Judith C. Sluimer, Dietbert Neumann,Pieter Goossens,Marjo M. P. C. Donners,
Cardiovascular Diabetologyno. 1 (2024): 1-17
FRONTIERS IN IMMUNOLOGY (2024): 1286382-1286382
International journal of molecular sciencesno. 8 (2023): 7309-7309
STAR PROTOCOLSno. 4 (2023): 102601-102601
Frontiers in Immunology (2023): 1165306
Cell metabolismno. 8 (2022): 1214-1225.e6
V. Saar-Kovrov, A. Pawlowska, J. Hermann,M.J. Gijbels,J. Sluimer,V. Jankowski,M.M.P.C. Donners,J. Jankowski,E.A.L. Biessen
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Author Statistics
#Papers: 84
#Citation: 2501
H-Index: 26
G-Index: 49
Sociability: 6
Diversity: 0
Activity: 0
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