Our laboratory pioneered a routine use of pancreas tissue slices to study the function of insulin-secreting beta cells in adult (Speier and Rupnik, 2003; Rupnik 2009), perinatal mice (Meneghel-Rozzo et al., 2004; Rozzo et al., 2009), normal and diabetic rats (Rose at al., 2007). We contributed to the knowledge-base on the function of KATP channels (Speier et al., 2005; Tsiaze et al, 2012), NMDA receptors (Marquard et al., 2015), and SNAP25b (Daraio et al., 2017) within an intact pancreatic tissue.