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Autophagy is a conserved cellular process in eukaryotic cells for the recycling of unwanted cytosolic constituents such as defunct organelles and protein aggregates in order to maintain cellular metabolism and homeostasis. Defects in autophagy have been linked to several diseases including cancer, neurodegeneration and diabetes. In addition, autophagy has been shown to play important roles in host immunity against infections. Autophagy functions in the direct engulfment and destruction of intracellular bacteria, parasites and viruses. Additional functions include antigen presentation of microbial and host antigens, control of inflammation, and immune cell survival and homeostasis. Our lab is studying autophagy process and its roles in infectious diseases of global importance. Our goals are to understand how autophagy is regulated during infections, how host cells employ this pathway to fight against infections and control inflammation, and how certain pathogens evade autophagic restriction by host cells or even subvert this pathway for their own benefits. We are currently using the human malarial parasite Plasmodium vivax, the bacterium Mycobacterium tuberculosis, and the Dengue virus infections as our study models.
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论文共 33 篇作者统计合作学者相似作者
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Kyaw Zwar Myint,Brinda Balasubramanian,Simran Venkatraman,Suchada Phimsen, Supisara Sripramote,Jeranan Jantra, Chaiwat Choeiphuk,Somkit Mingphruedhi,Paramin Muangkaew,Narongsak Rungsakulkij,Pongsatorn Tangtawee,Wikran Suragul,
Virusesno. 10 (2023): 2012
Peeraya Ekchariyawat, Rattatammanoon Saengfak,Sucharat Sanongkiet,Thanapon Charoenwongpaiboon, Suphasuta Khongpraphan, Supaporn Mala,Chularat Luangjindarat, Bumrung Munyoo,Napason Chabang,Sitthivut Charoensutthivarakul,Suparerk Borwornpinyo,Patoomratana Tuchinda,
PloS oneno. 11 (2023): e0292340-e0292340
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