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Bio
My research group performs pharmacogenetic research, from gene-finding to clinical implementation, aiming to optimise treatment for the individual patient. I started my group on pharmacogenetics focussing on gene-finding in rheumatoid arthritis, for which I set up a productive international collaboration. I led the first genome-wide association analysis for anti-TNF treatment outcome and the first large-scale genetic study showing how proxy measures for standard clinical outcomes can successfully be applied. Lately I focus the gene-finding research on pharmacogenetic studies in pediatrics and pain. Together with Dr. Maroeska te Loo, I set up the Genetics of Osteosarcoma (GO)-consortium, which includes thirteen (inter)national groups enabling us to assemble the world-wide largest cohort of children treated with platinum agents (including osteosarcoma and brain tumors). For the genetic studies in pain a study is ongoing that follows patients that undergo an operation for the development of acute and/or chronic. This cohort will be used for genetic studies to unravel the background of pain but also the pharmacogenetics of pain.
In addition to my gene-finding work, I have pushed the uptake of pharmacogenetics into clinical care. For this, I led the world-wide largest randomized controlled trial for cost-effectiveness of thiopurine-S-methyltransferase genotyping prior to thiopurine treatment in IBD. I am currently involved in similar multicentre studies. One in psychiatry investigating cost-effectiveness of pharmacogenetic testing prior to tricyclic anti-depressants treatment and a study investigating cost-effectiveness of pharmacogenetic testing prior to clopidogrel treatment in peripheral artrial disease.
Research Interests
Papers共 220 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
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合作机构
Clinical chemistry and laboratory medicine (2024)
Painno. 9 (2023): 1891-1911
Frontiers in pharmacology (2023): 1159307
Stefan A. J. Buck, Marinda Meertens, Frederiek M. F. van Ooijen,Esther Oomen-de Hoop,Evert de Jonge,Marieke J. H. Coenen,Andries M. Bergman,Stijn L. W. Koolen,Ronald de Wit,Alwin D. R. Huitema,Ron H. N. van Schaik,Ron H. J. Mathijssen
BIOMEDICINE & PHARMACOTHERAPY (2023): 115890-115890
The application of clinical genetics (2023): 131-137
Pharmacogenomicsno. 11 (2023): 629-639
JAMA NETWORK OPENno. 5 (2023): e2312443-e2312443
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Author Statistics
#Papers: 212
#Citation: 9808
H-Index: 48
G-Index: 96
Sociability: 8
Diversity: 0
Activity: 2
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