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Adverse health effects due to exposure to toxic metals, especially arsenic, cadmium, mercury and lead constitute serious public health problems world-wide. Major sources of exposure are drinking water and food. Ongoing research at the unit of Metals and Health focuses on effects of early-life exposure to toxic metals, both concurrent effects and effects later in life, effects on kidney, bone and immune function, as well as cancer development. A series of epidemiological studies concern two large cohorts, one mother-child cohort in Bangladesh, and one cohort of indigenous people in the Andean part of Argentina. The main metals of concern are arsenic and cadmium, but also lead. Recently, we have initiated studies on potential adverse effects of elevated intake of manganese via drinking water. We are investigating associations between exposures and adverse health effects, often including also various biomarkers of toxicity in order to increase the understanding of modes of actions. We are particularly interested in interactions with susceptibility factors, such as genetic polymorphisms, metabolism (especially for arsenic), and nutritional status. We collaborate with several research groups, both in Sweden and internationally, e.g. within the EU project PHIME. For measurements of small amounts of trace elements in biological tissues we use mainly Inductively Coupled Mass Spectroscopy (ICP-MS), often in combination with HPLC for separation of e.g. arsenic metabolites. We have clean-room facilities allowing detection of very low concentrations. In the last 5 years, the research has resulted in about 50 publications in renowned international scientific journals (average impact factor 3.7).
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Modern Inference Based on Health-Related Markerspp.187-212, (2024)
ENVIRONMENTAL RESEARCH (2024): 118355-118355
Journal of internal medicine (2023)
International journal of hygiene and environmental health (2023): 114116-114116
Journal of Internal Medicineno. 3 (2023): 358-369
ISEE Conference Abstractsno. 1 (2022)
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