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Bio
From the very beginning of my scientific career, the focus of my research has been tumor aggressiveness and therapies aimed to counteract it. My undergraduate and Ph.D. work at the National University of Rosario, Argentina, focused on murine lymphoma aggressiveness and its relationship with the expression of a pro-tumorigenic protein, along with the implementation of a chemotherapeutic regime. I showed that galectin-1 tumor expression is directly associated with a T-cell lymphoma aggressiveness and the antitumor and antimetastatic treatment with Cyclophosphamide targeted its expression. After completing my Ph.D. I joined VHIO and focused on the role of senescent cells on HER2+ breast cancer progression. I showed for the very first time that spontaneous and oncogene-induced senescent cells in this type of tumor contribute to its progression and aggressiveness through the production and secretion of a collection of different proteins. Importantly, by making use of different murine models and patient-derived tumors, I showed that interleukin-6, a protein exclusively produced by senescent cells, or its receptor, can be targeted in vivo with FDA-already approved drugs significantly decreasing tumor growth rate. I have finally joined the group of Dr. Laura Soucek, an expert in the biology of Myc, to study the effect of Myc inhibition in melanoma using Omomyc, a Myc dominant negative designed by Dr. Soucek, and to analyze the impact of the pharmacological application of Omomyc as a therapeutic polypeptide on the gene expression of tumors of different origins, in order to establish a core gene set of response to Omomyc.
Research Interests
Papers共 42 篇Author StatisticsCo-AuthorSimilar Experts
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Genes & developmentno. 7-8 (2023): 303-320
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S. Casacuberta Serra, S. Martínez-Martín, Í. González-Larreategui,S. López-Estévez,T. Jauset,M. Zacarías-Fluck,D. Massó-Vallés,G. Martín, L. Foradada,J. Grueso, E. Serrano,H. Thabussot,
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