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Bio
My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.
Research Interests
Papers共 303 篇Author StatisticsCo-AuthorSimilar Experts
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Montserrat Kwan,Maria-Luisa Alegre
American Journal of Transplantation (2024)
Jared M Pollard, Grace Hynes, Dengping Yin,Malay Mandal,Fotini Gounari,Maria-Luisa Alegre,Anita S Chong
JCI insight (2024)
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeonsno. 6 (2024): 933-943
Paolo Cravedi,Leonardo V Riella,Mandy L Ford,Anna Valujskikh,Madhav C Menon,Allan D Kirk,Maria-Luisa Alegre, Alessandro Alessandrini,Sandy Feng,Patricia Kehn, Nader Najafian, Wayne W Hancock,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2024)
American Journal of Transplantation (2024)
Research square (2023)
Frontiers in Transplantation (2023)
Transplantation (2023)
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American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeonsno. 10 (2023): 1526-1535
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