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个人简介
I obtained my PhD in 1993, in the field of Organic Chemistry and Natural Products (Supervisor: Prof. M. Grande, Universidad de Salamanca). In 1993, I moved to the EMBL in Heidelberg with a Post-doctoral research position in the group of Prof. H. Oschkinat, where I stayed five years. During this time, I developed a deep understanding of Structural Biology -in particular of NMR- applied to the determination of protein and nucleic acid structures in solution. I also got a solid knowledge of X-ray crystallography and Computational and Molecular Biology. During the years at the EMBL, we characterized the structures of several key signaling protein domains (PH and WW domains, Nature 1994, 1996) and of the double stranded RNA binding domain (EMBO J. 1995). These structures -the first ones of their kind- revealed how these domains adopted new folds, their interactions with ligands and their functional implications. We also succeeded in the de novo design of a WW domain, folded as the native counterpart (Nature Structural Biology 2000), and developed a protocol for the determination of protein structures in solution, named ARIA (JMB 1997), which is highly used worldwide.
In 1998, I started my career as an independent Staff-Scientist at the EMBL in Heidelberg. In 2002, my lab moved from Heidelberg to Barcelona, when I became an ICREA research professor and GL of the Macromolecular Assemblies group of the IRB Barcelona. We then started our journey to figure out why human bodies develop life-threatening diseases and how to use the tools provided by Structural Biology and Artificial Intelligence to identify new targets and vulnerable sites for drug action, to deploy new actions and treatments to improve the healthcare system and the quality of life of the patients.
研究兴趣
论文共 157 篇作者统计合作学者相似作者
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Alba Farrés,Pau Martín-Malpartida,Natalia Teixeira,Eva Magret,Cristina Soler, Raquel Muñoz, Rebeca A Mees,Alberto Gallardo,Pia Español,Maria J Macías,Ramon Rovira,María Virtudes Céspedes
Poster and E-Posters (2024)
Journal of Molecular Biologypp.168519, (2024)
Miriam Condeminas,Maria J. Macias
CURRENT OPINION IN STRUCTURAL BIOLOGY (2024): 102764-102764
Jimena Fernández-Carneado, Mariona Vallès-Miret,Sílvia Arrastia-Casado, Ana Almazán-Moga,Maria J. Macias, Pau Martin-Malpartida,Marta Vilaseca, Mireia Díaz-Lobo, Mayte Vazquez, Rosa M. Sanahuja, Gemma Gambús,Berta Ponsati
Nature Communicationsno. 1 (2023): 1-16
Nature Communicationsno. 1 (2023): 1-11
R. Pluta,M.J. Macias
crossref(2022)
Late breaking abstracts (2022)
R. Pluta,M.J. Macias
crossref(2022)
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