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个人简介
MARIA ANTONIETTA PANARO
PLACE AND DATE OF BIRTH:
Brindisi (Italy), November 27, 1964
POSITIONS HELD:
Ph D in Human and Experimental Morphology, University of Bari, Italy.
Aggregate Professor in Human Anatomy, University of Bari, Italy
TEACHING ACTIVITIES:
*Teacher for the Human Anatomy, University of Bari; Human Anatomy,
*Teacher for the PhD in “Applied Morphology, Biology and Drug Metabolism”, from 1999/2012.
RESEARCHES:
*Granulocytes and Macrophages: modulation of their biological activities (polarization, phagocytosis, killing, superoxide anion and nitric oxide release, inducible nitric oxide synthase induction, cytokine production and expression of cytokine receptors, apoptosis) by signaling molecules released from protozoa or bacteriA; chemotactic agents; pharmacological agents.
*DNA repair: modulation by LPS.
* Embryonal Cardiotoxicity of the Helicobacter pylori Lipopolysaccharide (LPS)
* Study of mediators of the inflammatory processes involved in neurodegeneration both in in vivo experimental models, represented by mice treated with MPTP, and y in vitro cultures of neurons and glial cells.
* Polyphenols: potential therapeutic applications of polyphenols related to diet in the course of chronic diseases on inflammatory basis: a) molecular mechanisms in vitro induced from polyphenols extracted from red wine on mononuclear cells isolated from peripheral blood, b) anti-inflammatory effects of resveratrol on colon carcinoma cells of human intestinal c) neuroprotective effects of resveratrol on experimental models in vivo and in vitro.
* Study of the evolution of devices related cellular receptor for the understanding of pathogenetic transduction mechanisms operating in mammals and man: in silico evolution studies of receptors for bacterial products (such as formylpeptides and LPS), for chemokines and other molecules involved in the responses of innate immunity.
* Study of newly synthesized molecules for anti-inflammatory and anti-tumor: a) selective inhibitors for the cyclo-oxygenase (COX) type 1 and 2; b) synthetic molecules acting modulating the expression and activity of P-gp usable for the purpose therapeutic for the treatment of cancer and neurodegenerative diseases.
研究兴趣
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Chiara Porro,Tarek Benameur,Antonia Cianciulli,Mirco Vacca, Margherita Chiarini,Maria De Angelis,Maria Antonietta Panaro
NUTRIENTSno. 6 (2024): 872
Giovanni Boero, Filippo Lauriero, Donato Fusillo,Rosa Calvello,Antonia Cianciulli,Maria Antonietta Panaro, Piergianni Moda
Clinical case reportsno. 7 (2024): e8974-e8974
Molecules (Basel, Switzerland)no. 8 (2023)
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
British Journal of Pharmacologyno. S2 (2023): S23-S144
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