Biochemical aspects of cytokine- and endotoxin-mediated phagocyte priming and cytoskeleton-mediated signal transduction were the topics of his studies. In 1992, he received a career development award (START) from the Swiss National Science Foundation. He created his own research group working on molecular mechanisms of signal transduction in leukocytes, focusing on PI 3-kinase-dependent pathways and chemokine-mediated receptor activation.