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Our group conduct innovative human immunology to study recirculating and resident memory CD8+ T cells in health and disease. These immune cells are absolutely critical for immune control of multiple chronic viral infections, such as HIV, and also represent a major cellular target of immune checkpoint therapies that have entirely revolutionized the treatment outcome in cancer care. However, many still view CD8+ T cells solely as killer T cells eliminating HIV-infected or tumor cells based on concepts from studies of peripheral blood. With emerging data from us and others demonstrating that many CD8+ T cells in tissues are non-cytolytic resident cells expressing multiple checkpoint molecules, such as PD-1, also in healthy subjects, it is tempting to speculate that these cells are designed to contain rather than eliminate tumors and virus-infected cells. This could be an evolutionary conserved process of the human body to minimize collateral tissue damage. Our group focus its work on many of these concepts with the aim to i) study the heterogeneity of circulating and resident memory CD8+ T cells in human donors, ii) identify alternative functions of memory CD8+ T cell in human tissues, iii) understand how memory CD8+ T cells maintain tumor and HIV control.
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论文共 162 篇作者统计合作学者相似作者
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Haematologicano. 2 (2024): 646-651
CELL HOST & MICROBEno. 2 (2024): 156-161.e3
D.N. Silva, G. Rovesti, H. Yao, P. Maravelia, F. Gatto, U. Sandvik, A. Fernandez, C. Chiavelli, M. Dominici, M. Sallberg,M. Buggert,H. Grönlund,
Cytotherapyno. 6 (2024): e26-e27
JOURNAL OF INFECTIOUS DISEASES (2024)
Wilhelm Hedin,Peter Bergman, Mily Akhirunessa,Sandra Söderholm,Marcus Buggert, Tobias Granberg,Sara Gredmark-Russ,C. I. Edvard Smith, Aleksandra Pettke,Emilie Wahren Borgström
JOURNAL OF IMMUNOLOGYno. 3 (2024): 389-396
biorxiv(2024)
Nature Immunologyno. 10 (2023): 1778-1778
SCIENCE IMMUNOLOGYno. 90 (2023): eadh0687-eadh0687
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