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职业迁徙
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Cell Signaling and Genome Maintenance: Damage to our genetic material is a threat to our survival and a driving force of many diseases. Our fundamental research interest is in the mechanisms of genome maintenance and we focus on the key roles of DNA damage checkpoint kinases (ATR, ATM, CHK1 and CHK2). We are using mass spectrometry technologies, in combination with genetic and biochemical approaches, to study the organization, dynamics and regulation of DNA damage signaling in yeast and humans. DNA Replication Stress: We are particularly interested in understanding how cells respond to DNA replication stress, a major endogenous source of DNA damage that drives cancer progression. In addition to its role in causing cancer, replication stress is also used to cure cancer. For example, numerous anti-cancer agents such as topoisomerase inhibitors, DNA crosslinkers and DNA alkylators, kill cancer cells by impairing the regulated progression of the replication machinery and inducing replication stress.
Cell Signaling and Genome Maintenance: Damage to our genetic material is a threat to our survival and a driving force of many diseases. Our fundamental research interest is in the mechanisms of genome maintenance and we focus on the key roles of DNA damage checkpoint kinases (ATR, ATM, CHK1 and CHK2). We are using mass spectrometry technologies, in combination with genetic and biochemical approaches, to study the organization, dynamics and regulation of DNA damage signaling in yeast and humans. DNA Replication Stress: We are particularly interested in understanding how cells respond to DNA replication stress, a major endogenous source of DNA damage that drives cancer progression. In addition to its role in causing cancer, replication stress is also used to cure cancer. For example, numerous anti-cancer agents such as topoisomerase inhibitors, DNA crosslinkers and DNA alkylators, kill cancer cells by impairing the regulated progression of the replication machinery and inducing replication stress.
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论文共 123 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Tegan S. Horan,Carolline F. R. Ascencao, Christopher A. Mellor,Meng Wang,Marcus B. Smolka,Paula E. Cohen
PLOS GENETICSno. 2 (2024): e1011175-e1011175
Bokun Xie,Ethan James Sanford,Shih-Hsun Hung, Mateusz Maciej Wagner,Wolf-Dietrich Heyer,Marcus B Smolka
bioRxiv : the preprint server for biology (2023)
Journal of Ovarian Researchno. 1 (2023): 1-13
bioRxiv : the preprint server for biology (2023)
Molecular Cellno. 20 (2023): 3588-3590
Research square (2023)
Journal of Biological Chemistryno. 3 (2023): 103813-S431
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