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职业迁徙
个人简介
Sandri group was the first to identify that protein breakdown requires a transcriptional-dependent program that regulates key and rate limiting enzymes of ubiquitin-proteasome and autophagy-lysosome systems. His lab also identified several unexpected links between pathways that control protein synthesis and muscle growth with the signalling of protein degradation. This knowledge was translated to several inherited muscle dystrophies and our lab was the first to identify autophagy impairment as a pathogenetic mechanism of muscle loss in Duchenne and Ullrich muscle dystrophies. Importantly, a nutritional-based clinical trial successfully showed that reactivation of autophagy is beneficial in patients. The connection between energy, mitochondria and nuclear programs that contrl the metabolic flexibility during exercise and how relevant is mitochondrial biogenesis and mitophagy are also topics in which Sandri lab greatly contributed in the last years. We now wish to understand how muscle programs that are under nutritional and physical activity/inactivity regulation systemically reverberate affecting distal organ function and life span.
研究兴趣
论文共 584 篇作者统计合作学者相似作者
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Valentina Cavedon,Paola Zuccolotto,Marco Sandri, Maricay Manisera,Marco Bernardi, Ilaria Peluso,Chiara Milanese
PloS oneno. 5 (2024): e0302596-e0302596
Marcio Covas Moschovas, Abdel Jaber,Shady Saikali,Marco Sandri,Seetharam Bhat,Travis Rogers,Ahmed Gamal,David Loy,Evan Patel, Sumeet Reddy,Maria Chiara Sighinolfi, Bernardo Rocco,
European urology focus (2024)
Valerio Iacovelli, Marco Carilli,Marco Sandri,Valerio Forte, Alessandro Antonelli, Antonio Celia, Roberto Falabella,Costantino Leonardo,Andrea Minervini, Antonio Luigi Pastore, Giulio Patruno,Silvia Secco,
Continence (2024): 101292
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Marco Scalabrin, Eloisa Turco,Leonardo Nogara,Gaia Gherardi, Giulia Trani,Samuele Negro, Anais Franco Romero,Yorrick Jaspers,Elisa Baschiera,Rossella De Cegli, Eugenio Del Prete,Tito Cali,
crossref(2024)
ASIAN JOURNAL OF UROLOGYno. 1 (2024): 19-25
Pediatric pulmonologyno. 5 (2024): 1339-1345
Horticulture Researchno. 5 (2023)
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