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Research summary
My current research is focussed on the characterization of premotor interneurons in the ventral horn of the spinal cord. Premotor networks are involved in all motor circuits and are responsible for the coordination of locomotor activity and for the execution and tuning of all motor tasks.
My main aim is to describe the properties of the network of premotor interneurons in relation to their function and to characterize individual synaptic connections.
In the past I have studied the kinetic of glycine receptors using single channel recordings and fast concentration jumps techniques, combined with mathematical modeling and kinetic analysis. Now I am using electrophysiological recordings to record from multiple cells and from synaptically connected interneuron-motoneuron pairs in slices or in the en-bloc spinal cord.
In collaboration with Professors Andrew Todd and David Maxwell (University of Glasgow) we have characterized glycinergic premotor interneurons and measured the strength of Renshaw cells synapses onto motoneurons. We will now use a rabies based trans-synaptic tracer to label networks of flexor and extensor related premotor interneurons and to drive the expression of channelrhodopsin. Our aim is to determine a map of functional connectivity and to relate it to the electrophysiological and neurochemical profiles of premotor interneurons.
Quantal analysis methods and kinetic modeling are used to characterize the properties of synapses.
My work is funded by a Royal Society University Research Fellowship, by the Leverhulme Trust and by a BBSRC project grant (joint with the University of Glasgow).
My current research is focussed on the characterization of premotor interneurons in the ventral horn of the spinal cord. Premotor networks are involved in all motor circuits and are responsible for the coordination of locomotor activity and for the execution and tuning of all motor tasks.
My main aim is to describe the properties of the network of premotor interneurons in relation to their function and to characterize individual synaptic connections.
In the past I have studied the kinetic of glycine receptors using single channel recordings and fast concentration jumps techniques, combined with mathematical modeling and kinetic analysis. Now I am using electrophysiological recordings to record from multiple cells and from synaptically connected interneuron-motoneuron pairs in slices or in the en-bloc spinal cord.
In collaboration with Professors Andrew Todd and David Maxwell (University of Glasgow) we have characterized glycinergic premotor interneurons and measured the strength of Renshaw cells synapses onto motoneurons. We will now use a rabies based trans-synaptic tracer to label networks of flexor and extensor related premotor interneurons and to drive the expression of channelrhodopsin. Our aim is to determine a map of functional connectivity and to relate it to the electrophysiological and neurochemical profiles of premotor interneurons.
Quantal analysis methods and kinetic modeling are used to characterize the properties of synapses.
My work is funded by a Royal Society University Research Fellowship, by the Leverhulme Trust and by a BBSRC project grant (joint with the University of Glasgow).
Research Interests
Papers共 69 篇Author StatisticsCo-AuthorSimilar Experts
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BRAINno. 2 (2024): 406-413
iSciencepp.110444, (2024)
bioRxiv : the preprint server for biology (2024)
eLife (2022)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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Author Statistics
#Papers: 69
#Citation: 2650
H-Index: 32
G-Index: 51
Sociability: 5
Diversity: 3
Activity: 27
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