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Dr. Kazanietz studies the receptors for the phorbol ester tumor promoters and the second messenger diacylglycerol (DAG), an important intracellular mediator of proliferation and malignant transformation. His lab is exploring the role of PKC isozymes (the main phorbol ester/DAG receptors) in prostate carcinogenesis,and the signal transduction pathways regulated by each PKC isozyme, including the MAPK cascades and Akt/PKB. The second area of research involves the "chimaerins", novel phorbol ester/DAG receptors with Rac-GAP activity. Rac is a small GTP-binding protein that regulates actin cytoskeleton organization, cell cycle progression, gene expression, adhesion and migration. He is currently focusing on the cellular functions of chimaerin isoforms and we are isolating interacting proteins that control their subcellular localization and activity.
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Research Square (Research Square)no. 1 (2024): 13-13
CELL DEATH DISCOVERYno. 1 (2024)
The Journal of biological chemistryno. 3 (2024): 105692-105692
JOURNAL OF BIOLOGICAL CHEMISTRYno. 8 (2023)
Rachana Garg,Mariana Cooke,Fernando Benavides,Martín C. Abba, Michelle Cicchini,David M. Feldser,Marcelo G. Kazanietz
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Journal of Cell Scienceno. 20 (2023)
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Yanshan Liu,Siddharth Banka,Yingzhi Huang,Jonathan Hardman,Derek Pye,Antonio Torrelo, Glenda Beaman,Marcelo G. Kazanietz, Martin Baker,Carlo Ferrazzano,Chenfu Shi,Gisela Orozco,
EUROPEAN JOURNAL OF HUMAN GENETICS (2023): 555-555
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