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Using the immune system as a cancer treatment has the potential to induce long-term, durable remissions, and perhaps even cures for some patients. The T cells of the immune system are able to specifically kill the target cells they recognize. T cells are also able to persist in the body for many years, and form immune ‘memory,’ which enables the possibility of long-term protection. The Maus laboratory is interested in using genetic engineering techniques to re-direct T cells to find and kill tumor cells while sparing healthy tissues. We aim to: develop new ways to design molecular receptors to target T cells to liquid and solid tumors; use T cells as delivery vehicles for other drugs, and use drugs to help T cells work against tumors; and understand how T cells can work as “living drugs” to treat patients with cancer.
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crossref(2024)
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Felix Korell,Michael L Olson,Diego Salas-Benito,Mark B Leick,Rebecca C Larson,Amanda Bouffard,Harrison Silva, Alessandro Gasparetto,Trisha R Berger,Michael C Kann, Markus Mergen,Tamina Kienka,
Science translational medicineno. 750 (2024): eadk7640-eadk7640
Blood advancesno. 4 (2024): 1053-1061
crossref(2024)
crossref(2024)
Cancer Researchno. 6_Supplement (2024): 34-34
Eli P. Darnell,Marcela V. Maus
Trends in cancerno. 4 (2024): 312-331
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