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The research of my group focuses on understanding the biological processes that lead to abnormal usage of genetic information in disease, in particular via so-called ‘epigenetic’ mechanisms. Epigenetic means a modification of the DNA and associated chromatin that changes the expression pattern of genes without changing the DNA sequence of the genes. DNA methylation of cytosine residues at CpG dinucleotides is one example of epigenetic gene regulation. In addition, the packaging of the DNA into regions of active and silent chromatin is another example. These mechanisms are often deregulated in cancer leading to over-expression or silencing of critical genes. But also in many other diseases it has now become apparent that both genetic and epigenetic events are responsible for the observed phenotype.
Our area of interest can be divided into three main topics:
1) Understanding epigenetic mechanisms and their deregulation in diseases.
2) The interplay between genetics and epigenetics.
3) The development of novel assays for epigenetic testing.
One of the ongoing projects in the group concerns epigenetic changes in prostate cancer where we identified that such changes can encompass large chromosomal regions resulting in silencing of many neighbouring genes (“Long Range Epigenetic Silencing” or LRES). Current work focuses around a further understanding of the underlying mechanism(s).
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Papers共 31 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2023)
TWIN RESEARCH AND HUMAN GENETICSno. 4 (2013): 767-781
Genome researchno. 6 (2012): 1120-7
EPIGENETICS: A REFERENCE MANUALpp.371-392, (2011)
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#Papers: 32
#Citation: 1977
H-Index: 21
G-Index: 32
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