My research aim is to provide the evidence base to enable people at risk of mycobacterial disease, including TB and related conditions such as HIV infection, to access and obtain highest-quality care. My work concerns the interaction between the human host, the microbe and the environment in which they find themselves. It focuses on three main areas: 1. operational & economic health services research (including management of the hard to reach and hard to treat, service evaluation, & modelling of infection), 2. diagnostics (both microbiology and immune-based), 3. treatment and treatment responses in HIV negative and co-infected individuals (including therapy-related paradoxical reactions).