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Mitochondria are the organelles responsible for our need to breathe, as they use oxygen both to transform nutrients into usable energy and to build essential components constituting our bodies. Indeed, mitochondria are semi-autonomous organelles that contain their own genome, which encodes for 13 proteins essential to consume oxygen. For this reason, mitochondrial DNA mutations that blunt their capacity to consume oxygen are responsible of lethal and severe diseases. Moreover, changes in mitochondrial function are detected in neurodegenerative diseases, as well as in pathologies resulting of an imbalance in energy consumption, energy expenditure and nutrient handling, such as obesity and type 2 diabetes. Furthermore, the reduction in mitochondrial function observed with age is considered a major component driving fitness decline with age. In this context, our overarching research goals are:
1) Define the molecular machinery by which mitochondria can successfully adapt, protect themselves and execute their function in health.
2) Determine when the crosstalk between mitochondria and the redox state contribute to exacerbate metabolic diseases or represent an adaptation preventing their exacerbation.
3) Test whether the manipulation of the molecular machinery modulating and adapting mitochondrial function can be used to treat metabolic diseases.
Mitochondria are the organelles responsible for our need to breathe, as they use oxygen both to transform nutrients into usable energy and to build essential components constituting our bodies. Indeed, mitochondria are semi-autonomous organelles that contain their own genome, which encodes for 13 proteins essential to consume oxygen. For this reason, mitochondrial DNA mutations that blunt their capacity to consume oxygen are responsible of lethal and severe diseases. Moreover, changes in mitochondrial function are detected in neurodegenerative diseases, as well as in pathologies resulting of an imbalance in energy consumption, energy expenditure and nutrient handling, such as obesity and type 2 diabetes. Furthermore, the reduction in mitochondrial function observed with age is considered a major component driving fitness decline with age. In this context, our overarching research goals are:
1) Define the molecular machinery by which mitochondria can successfully adapt, protect themselves and execute their function in health.
2) Determine when the crosstalk between mitochondria and the redox state contribute to exacerbate metabolic diseases or represent an adaptation preventing their exacerbation.
3) Test whether the manipulation of the molecular machinery modulating and adapting mitochondrial function can be used to treat metabolic diseases.
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Methods in molecular biology (Clifton, N.J.) (2023): 53-65
STAR protocolsno. 3 (2023): 102408-102408
Jennifer Ngo,Dong Wook Choi,Illana A Stanley,Linsey Stiles,Anthony J A Molina,Pei-Hsuan Chen,Ana Lako, Isabelle Chiao Han Sung,Rishov Goswami, Min-Young Kim,Nathanael Miller,Siyouneh Baghdasarian,
The EMBO journalno. 11 (2023): e111901-e111901
Life science allianceno. 4 (2023): e202201628-e202201628
Blood Cancer Discoveryno. 5_Supplement (2022): A07-A07
biorxiv(2022)
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