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Research objectives
Determine why the intestinal epithelia is particularly vulnerable to oncogenic mutations in the tumour suppressor APC.
Define whether the oncogenic form of the Wnt pathway is a bone fide therapeutic target in colon cancer.
Molecular and clinical characterization of a subset of colon cancer stratified by specific mutations in TCF7L2.
Determine why the intestinal epithelia is particularly vulnerable to oncogenic mutations in the tumour suppressor APC.
Define whether the oncogenic form of the Wnt pathway is a bone fide therapeutic target in colon cancer.
Molecular and clinical characterization of a subset of colon cancer stratified by specific mutations in TCF7L2.
研究兴趣
论文共 26 篇作者统计合作学者相似作者
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Ciara Metcalfe, Ashraf E.K. Ibrahim, Michael Graeb,Marc de la Roche, Thomas Schwarz-Romond,Marc Fiedler,Douglas J. Winton, Anthony Corfield,Mariann Bienz
crossref(2023)
Ciara Metcalfe,Ashraf E.K. Ibrahim, Michael Graeb,Marc de la Roche,Thomas Schwarz-Romond,Marc Fiedler,Douglas J. Winton, Anthony Corfield,Mariann Bienz
crossref(2023)
Ciara Metcalfe,Ashraf E.K. Ibrahim, Michael Graeb,Marc de la Roche,Thomas Schwarz-Romond,Marc Fiedler,Douglas J. Winton, Anthony Corfield,Mariann Bienz
crossref(2023)
Ciara Metcalfe, Ashraf E.K. Ibrahim, Michael Graeb,Marc de la Roche, Thomas Schwarz-Romond,Marc Fiedler,Douglas J. Winton, Anthony Corfield,Mariann Bienz
crossref(2023)
Ciara Metcalfe, Ashraf E.K. Ibrahim, Michael Graeb,Marc de la Roche, Thomas Schwarz-Romond,Marc Fiedler,Douglas J. Winton, Anthony Corfield,Mariann Bienz
crossref(2023)
crossref(2023)
Ciara Metcalfe, Ashraf E.K. Ibrahim, Michael Graeb,Marc de la Roche, Thomas Schwarz-Romond,Marc Fiedler,Douglas J. Winton, Anthony Corfield,Mariann Bienz
crossref(2023)
Hung-Chang Chen, Nico Mueller,Katherine Stott, Eilidh Rivers,Chrysa Kapeni,Carolin M Sauer,Flavio Beke,Stephen Walsh,Nicola Ashman,Louise O’Brien, Amir Rafati Fard, Arman Godsinia,
biorxiv(2022)
Inderpreet Sur, Wenshuo Zhao,Jilin Zhang, Margareta Kling Pilstrom,Björn Rozell, Andrew C. Webb, Cheng Ho,Ari Ristimäki,Pekka Katajisto,Martin Enge,Helena Rannikmae,Marc de la Roche,
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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Inflammatory Bowel Diseasesno. 3 (2022): S3-S3
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