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We investigate the molecular mechanisms by which eukaryotic cells survive to adverse circumstances. In particular, we study the unique regulation of the genes activated in response to stress using single-molecule imaging approaches. Our research aims to decipher how cells produce the components of the stress response, the heat shock proteins (HSPs), at the expense of shutting-down specific and general functions. The HSPs are families of molecular chaperones with cytoprotective properties. They recognize denatured proteins, fold them, and prevent their toxic aggregation. Once protein homeostasis is recovered, cells restore their functions and precisely cease the production of HSPs. The success of the stress response relays on the tight and unique regulation of the life-cycle of HSP mRNAs. The unbalanced expression of HSPs leads to a variety of diseases that ranges from cancer to neurodegeneration.
We investigate the molecular mechanisms by which eukaryotic cells survive to adverse circumstances. In particular, we study the unique regulation of the genes activated in response to stress using single-molecule imaging approaches. Our research aims to decipher how cells produce the components of the stress response, the heat shock proteins (HSPs), at the expense of shutting-down specific and general functions. The HSPs are families of molecular chaperones with cytoprotective properties. They recognize denatured proteins, fold them, and prevent their toxic aggregation. Once protein homeostasis is recovered, cells restore their functions and precisely cease the production of HSPs. The success of the stress response relays on the tight and unique regulation of the life-cycle of HSP mRNAs. The unbalanced expression of HSPs leads to a variety of diseases that ranges from cancer to neurodegeneration.
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Mario Fernández Comaduran,Sandra Minotti,Suleima Jacob-Tomas, Javeria Rizwan, Nancy Larochelle,Richard Robitaille,Chantelle F. Sephton,M. Vera,Josephine N. Nalbantoglu,Heather D. Durham
Cell Stress and Chaperonesno. 3 (2024): 359-380
Celia Alecki, Javeria Rizwan,Phuong Le,Suleima Jacob-Tomas, Jia Stella M Xu,Sandra Minotti, Tad Wu,Heather Durham,Gene W Yeo,Maria Vera
bioRxiv : the preprint server for biology (2023)
INTERNATIONAL JOURNAL OF HUMAN RESOURCE MANAGEMENTno. 5 (2023): 912-940
FRONTIERS IN GENETICS (2022): 823241
Lokha R. Alagar Boopathy,Emma Beadle, Alan Xiao, Aitana Garcia-Bueno Rico,Celia Alecki,Irene Garcia de-Andres,Maria Vera
biorxiv(2022)
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