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The CNS laboratory incorporates advanced and unique methods of magnetic resonance imaging (MRI) techniques including functional MRI (fMRI), diffusion tensor MRI (dMRI), and resting state fMRI (rsfMRI). Employing dMRI in conjunction with fMRI technique, our research has successfully demonstrated that functional and structural aspect of the human visual pathways are substantially remodeled following vision restoration.
At CAROT, the neuroimaging project builds upon expertise across multiple fields of science and medicine with a unique access to group of patients regaining vision through gene therapy to gain a deeper understanding of the partnership between the brain and retina and its potential to uncover the underlying process of human brain plasticity. This type of knowledge on brain plasticity of visual systems currently comes largely from animal models with visual impairment followed by vision restoration. Based on our preliminary data, our hope is to develop innovative rehabilitation program that are centered on an alternate brain pathway (used by low vision patients) to enhance visual function in patients who are not currently candidate for retinal gene therapy.
The CNS lab has participated in all three phases of the Leber’s congenital Amaurosis (LCA) clinical trials that have taken place at The Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania (Upenn). We were the first to describe the restoration of visual pathways in humans after retinal gene therapy
At CAROT, the neuroimaging project builds upon expertise across multiple fields of science and medicine with a unique access to group of patients regaining vision through gene therapy to gain a deeper understanding of the partnership between the brain and retina and its potential to uncover the underlying process of human brain plasticity. This type of knowledge on brain plasticity of visual systems currently comes largely from animal models with visual impairment followed by vision restoration. Based on our preliminary data, our hope is to develop innovative rehabilitation program that are centered on an alternate brain pathway (used by low vision patients) to enhance visual function in patients who are not currently candidate for retinal gene therapy.
The CNS lab has participated in all three phases of the Leber’s congenital Amaurosis (LCA) clinical trials that have taken place at The Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania (Upenn). We were the first to describe the restoration of visual pathways in humans after retinal gene therapy
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