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个人简介
Dr. Perucho studies tumors from the intestinal tract that sometimes develop when the cellular machinery preserving the integrity of the genome – like computer spell-check programs that detect errors and correct them – is not working properly. When these corrector genes (mutators) are inactivated, the mutations that occur in all normal cells accumulate in large numbers because they are not repaired. This sparks genomic instability and cancer eventually develops when mutations occur in some cancer genes, such as oncogenes and tumor suppressor genes. However, some mutator genes are not inactivated by mutations, but by epigenetic silencing. This results from the disintegration of the epigenetic code, an unexplored process that is strongly associated with aging. This is important because many hereditary colon tumors originate by mutations in mutator genes that are transmitted from generation to generation. Molecular diagnosis of the deficient mutator genes determines which members of these families will be affected in the future. Identification of tumors with this kind of genomic instability is also useful for detecting familial cancer patients and predicting survival.
研究兴趣
论文共 220 篇作者统计合作学者相似作者
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Beatriz González, Maria Navarro-Jiménez, María José Alonso-De Gennaro, Sanne Marcia Jansen,Isabel Granada,Manuel Perucho,Sergio Alonso
Iván Galván-Femeníaa,Marta Guindob, Xavier Durana,Sílvia Calabuig-Fariñasc,Josep Maria Mercaderb,Jose Luis Ramirezf, Rafael Rosellf,David Torrentsb,Anna Carrerasa,Takashi Kohnoh,Eloisa Jantus-Lewintred, Carlos Campsc,
semanticscholar(2018)
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Ivan Galvan-Femenia,Mireia Obon-Santacana,David Pineyro,Marta Guindo-Martinez,Xavier Duran,Anna Carreras,Raquel Pluvinet,Juan Velasco,Laia Ramos,Susanna Ausso, J. M. Mercader, Lluis Puig,
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