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个人简介
Major research focus of my lab is to study the mechanisms by which nucleus pulposus cells of the intervertebral disc adapt to avascular (hypoxic) and osmotically compromising environment. In this regard, we are studying role of transciption factors HIFs and TonEBP and signaling events that control their function. Another major research interest is to device tissue-enginering based strategies for intervertebral disc regeneration. We are testing hypothesis that adult mesenchymal stem cells (MSC) transplanted into the disc will assume nucleus pulposus-like phenotype and achieve functional restoration of degenerate disc. Our recent work shows that MSC differentiate into nucleus pulposus-like cells when cultured under conditions similar to that exist in the disc in vivo. A whole disc organ culture is also under investigation to understand aspects of disc cell function in an ex vivo setting.
研究兴趣
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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024)
Bone (2024): 117112-117112
Bone Researchno. 1 (2024): 1-12
NEUROSPINEno. 1 (2024): 162-178
Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman,Kimheak Sao, Kameron Inguito, Owen Haslam,Paige K Boneski,Hiromi Sesaki,John A Collins,Makarand V. Risbud
bioRxiv the preprint server for biology (2024)
Frontiers in cell and developmental biology (2024): 1360376-1360376
Makarand Risbud,Vedavathi Madhu, Miriam Hernandez-Meadows, Ashley Coleman,Kimheak Sao, Kameron Inguito, Owen Haslam,Paige Boneski,Hiromi Sesaki,John Collins
Research square (2024)
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