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个人简介
A physician-scientist, she is widely recognized for her animal model and clinical research on the role of microbial, immune and toxic factors in the development of brain conditions including autism, attention-deficit/hyperactivity disorder (ADHD), Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection (PANDAS), mood disorders, schizophrenia, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and cognitive disorders of aging. She is particularly interested in fetal programming of central nervous system (CNS) disorders that manifest across the life span, ranging from neurodevelopmental disorders such as autism to mood and cognitive disorders in adulthood and later life. She is internationally known for establishing animal models focused on how genes and age-related factors interact with microbes and other environmental agents to lead to inflammation and autoimmune phenomena that disrupt brain development and function. She uses immune profiling, metabolomic, proteomic, epigenetic and microbiome approaches to identify prenatal and birth biomarkers for a wide range of neuropsychiatric disorders, including autism and ADHD, in the large, prospective MoBa Study in Norway and other pregnancy/birth cohorts. She is applying similar approaches to uncover markers of disturbed immunity and metabolism that correlate with the clinical deficits of disabling diseases such as ME/CFS, with support from the Hutchins Family Foundation/Chronic Fatigue Initiative (CFI) and NIH.
研究兴趣
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Brain, Behavior, & Immunity - Health (2023): 100720-100720
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