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Satellite DNA function within species and beyond
Satellite DNA are simple tandem repeats that exist at centromeric and pericentromeric regions on eukaryotic chromosomes. While the role of centromeric satellite DNA is well characterized, function(s) for the much more abundant pericentromeric satellite DNA repeats is poorly understood. Indeed, current dogma suggests that pericentromeric satellite DNA are ‘junk’ because these simple repeats possess no coding function and there is a striking lack of conservation in the primary sequence between closely related species. Arguing against the ‘junk DNA’ hypothesis, the abundance of pericentromeric satellite DNAs is remarkably stable over multiple generations, despite being prone to copy number loss and posing a significant burden on cellular resources. These observations suggest that pericentromeric satellite DNAs must serve an unappreciated function(s), which has remained undiscovered. We are currently interested in the following questions regarding pericentromeric satellite DNAs – (a) why do they exist? (b) how do they function? and (c) what is the significance of their divergence?
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Since Membership
2020 Society for Molecular Biology and Evolution
2019 Molecular Life Sciences Program, LSZGS
2014 Genetics Society of America
Satellite DNA function within species and beyond
Satellite DNA are simple tandem repeats that exist at centromeric and pericentromeric regions on eukaryotic chromosomes. While the role of centromeric satellite DNA is well characterized, function(s) for the much more abundant pericentromeric satellite DNA repeats is poorly understood. Indeed, current dogma suggests that pericentromeric satellite DNA are ‘junk’ because these simple repeats possess no coding function and there is a striking lack of conservation in the primary sequence between closely related species. Arguing against the ‘junk DNA’ hypothesis, the abundance of pericentromeric satellite DNAs is remarkably stable over multiple generations, despite being prone to copy number loss and posing a significant burden on cellular resources. These observations suggest that pericentromeric satellite DNAs must serve an unappreciated function(s), which has remained undiscovered. We are currently interested in the following questions regarding pericentromeric satellite DNAs – (a) why do they exist? (b) how do they function? and (c) what is the significance of their divergence?
Membership
Since Membership
2020 Society for Molecular Biology and Evolution
2019 Molecular Life Sciences Program, LSZGS
2014 Genetics Society of America
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Noor M Kotb, Gulay Ulukaya,Ankita Chavan,Son C Nguyen, Lydia Proskauer,Eric Joyce,Dan Hasson,Madhav Jagannathan,Prashanth Rangan
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Ankita Chavan,Randi Isenhart,Son C Nguyen,Noor Kotb,Jailynn Harke, Anna Sintsova, Gulay Ulukaya,Federico Uliana,Caroline Ashiono,Ulrike Kutay,Gianluca Pegoraro,Prashanth Rangan,
bioRxiv : the preprint server for biology (2023)
Ankita Chavan, Lena Skrutl, Federico Uliana, Melanie Pfister,David Burke, Franziska Brändle, Pedro Beltrao,Madhav Jagannathan
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2021)
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