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Cell death is a fundamental cellular response that plays a crucial role both during development and in the removal of unwanted or damaged cells following stress, injury or infection. Inappropriate cell death regulation contributes to many human diseases, including cancer and autoimmune and neurodegenerative disorders. Proteins/pathways that control cell death have also been identified as defined nodes that form key decision points to regulate the response to toxic insult.
Our Programme is aimed at understanding the fundamental mechanisms of cell death that regulate life/death decisions at the cellular level. By understanding the underlying molecular and cell biology of these processes, we aim to deliver field-changing mechanistic insights into toxicology and disease.
Our research Objectives are to develop a number of strategies including develop a number of strategies including novel ‘in vitro’ reconstituted models which, combined with an integrated molecular, cell biological and proteomics-based approach, place us in a prime position to examine the molecular determinants of cell death.
Cell death is a fundamental cellular response that plays a crucial role both during development and in the removal of unwanted or damaged cells following stress, injury or infection. Inappropriate cell death regulation contributes to many human diseases, including cancer and autoimmune and neurodegenerative disorders. Proteins/pathways that control cell death have also been identified as defined nodes that form key decision points to regulate the response to toxic insult.
Our Programme is aimed at understanding the fundamental mechanisms of cell death that regulate life/death decisions at the cellular level. By understanding the underlying molecular and cell biology of these processes, we aim to deliver field-changing mechanistic insights into toxicology and disease.
Our research Objectives are to develop a number of strategies including develop a number of strategies including novel ‘in vitro’ reconstituted models which, combined with an integrated molecular, cell biological and proteomics-based approach, place us in a prime position to examine the molecular determinants of cell death.
研究兴趣
论文共 136 篇作者统计合作学者相似作者
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Gilda Giancotti,Rhiannon French, Olivia Hayward,Kok Yung Lee, Timothy Robinson, Andreia M. Ribeiro da Silva,Athina Varnava,Marion MacFarlane,Richard W.E. Clarkson,Andrew D. Westwell,Andrea Brancale
biorxiv(2024)
Constantinos Demetriou, Naila Abid,Michael Butterworth,Larissa Lezina,Pavandeep Sandhu,Lynne Howells,Ian R Powley,James H Pringle,Zahirah Sidat, Omar Qassid, Dave Purnell,Monika Kaushik,
Scientific reportsno. 1 (2024): 12833-12833
crossref(2023)
Frontiers in toxicology (2023): 1200650-1200650
Biology Directno. 1 (2023): 43-17
Juan Carlos Yam-Puc,Zhaleh Hosseini,Emily C. Horner,Pehuén Pereyra Gerber,Nonantzin Beristain-Covarrubias,Robert Hughes,Aleksei Lulla,Maria Rust,Rebecca Boston, Magda Ali,Katrin Fischer, Edward Simmons-Rosello,
biorxiv(2023)
Kristel Martinez Lagunas,Deniz Pinar Savcigil, Matea Zrilic, Carlos Carvajal Fraile,Andrew Craxton,Emily Self,Iratxe Uranga-Murillo,Diego de Miguel,Maykel Arias,Sebastian Willenborg, Michael Piekarek,Marie Christine Albert,
crossref(2023)
Dominic Stadel,Andrea Mohr, Caroline Ref,Marion MacFarlane,Shaoxia Zhou,Robin Humphreys,Max Bachem, Gerry Cohen,Peter Möller,Ralf M. Zwacka,Klaus-Michael Debatin,Simone Fulda
crossref(2023)
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作者统计
#Papers: 133
#Citation: 15364
H-Index: 46
G-Index: 123
Sociability: 7
Diversity: 0
Activity: 1
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