基本信息
views: 3
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
I completed my undergraduate studies in molecular biology at California State University, Fullerton, a Latinx-serving institution in Southern California. I was first exposed to laboratory research after taking a molecular biology and genetics course. My professor, Dr. Amybeth Cohen, encouraged me to volunteer in her lab. With the support of the Research Careers Preparatory Program (RCP), a program that supported and trained its students in how to efficiently volunteer in laboratories at CSUF, I began to gain excitement for bench research. After my initial exposure to research in the Cohen lab, I applied to and was accepted in the NIH-funded Minority Access to Research Careers (MARC) program. I decided to remain in the Cohen lab after beginning the MARC program as I had established a strong working relationship with Dr. Cohen and lab members. During my participation in the MARC program, I directed and conducted all experiments to discover and characterize a novel red light photoreceptor in the unicellular green alga Chlamydomonas reinhardtii utilizing Bioinformatics, PCR, and Southern blots. Participating in the Cohen lab during the MARC program helped me develop my technical and critical thinking skills while providing the confidence and support of the MARC community to participate in several outreach events, such as mentoring undergraduate students, in and outside the lab. It was during my time in the MARC program that I realized I not only enjoyed the scientific process but also found a sense of fulfillment in leadership and mentorship.
Once I graduated from Cal State Fullerton, I was able to pursue my scientific mission of understanding the brain at the molecular level by participating in the NIH-funded Post-baccalaureate Research Education Program (PREP) at UNC-Chapel Hill in the laboratory of Benjamin Philpot. Using mouse models, the Philpot lab studies the molecular pathophysiology of Angelman syndrome (AS), a neurodevelopmental disorder characterized by lack of speech, seizures, and motor impairment. The goal of my project was to identify the reasons why a mutated ubiquitin ligase called UBE3A leads to AS pathology by identifying substrates for UBE3A, describing its roles in neural development. My PREP research experience in the Philpot lab solidified my curiosity for studying gene expression in the brain. While in PREP at UNC-Chapel Hill, I applied to graduate programs across the country.
I chose to focus my graduate work on studying the role of microRNAs in microglia and myeloid cell activation during Alzheimer’s disease (AD), the most common form of age-associated dementia. In the Garden lab, I had the opportunity to learn and become proficient in complex techniques used to study glial cells in vitro and in vivo (eg. Tissue culture systems, complex mouse genetic studies). I was able to establish collaborations with multiple labs across the University of Washington (Barker-Halliski, de La Iglesia lab, and Keene lab), as well as learn and master techniques outside of my direct field of research. I contributed to multiple projects in the lab that have to lead to publications. I recently joined the lab of Jeffery Noebels at Baylor College of Medicine in Houston, Texas as a post-doctoral trainee. Here, I focus on understanding the contribution of glia and microglia in hyperexcitability and epileptogenesis of the brain during development and in Alzheimer’s disease pathogenesis.
Research Interests
Papers共 13 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
npj Mental Health Researchno. 1 (2023): 1-8
NEUROPSYCHOPHARMACOLOGY (2022): 335-336
Cited0Views0Bibtex
0
0
GLIAno. 7 (2021): 1736-1748
Katherine E Prater,Macarena S Aloi,Jasmine L Pathan,Chloe N Winston, Rachel A Chernoff,Stephanie L Davidson, Matthew Sadgrove,Ashley McDonough,Dannielle K Zierath,Wei Su,Jonathan R Weinstein,Gwenn A Garden
M. S. Aloi,K. Prater,R. Hu,J. Pathan, S. Davidson, B. Sopher,R. Sanchez,H. De La Iglesia,S. Jayadev,G. Garden
Cited0Views0Bibtex
0
0
Peter J Amos,Susan Fung,Amanda Case, Jerusalem Kifelew,Leah Osnis,Carole L Smith,Kevin Green,Alipi Naydenov,Macarena Aloi,Jesse J Hubbard,Aravind Ramakrishnan,Gwenn A Garden,
Load More
Author Statistics
#Papers: 12
#Citation: 210
H-Index: 5
G-Index: 9
Sociability: 4
Diversity: 2
Activity: 8
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn