Dr. Younes research focus is mainly biomarkers and translational research. Some highlights of his research include:

p53 protein overexpression in Barrett’s esophagus and correlation with risk of malignant progression.
Expression of glucose and amino acid transporters (Glut1, Glut3, ASCT1, ASCT2) in benign and malignant human tissues and the clinical significance of their expression in colorectal cancer.
Estrogen receptor beta expression in breast cancer and correlation with response to adjuvant tamoxifen therapy, and also estrogen receptor beta isoform expression in various digestive system tumors including colon cancer, esophageal cancer, and pancreatic cancer.
Biomarker expression in inflammatory bowel disease and correlation with treatment with biologics (ongoing interest)
Biomarker expression in nonalcoholic fatty liver disease NAFLD/NASH and prediction of risk of progression to hepatocellular carcinoma (ongoing interest).