基本信息
浏览量:167
职业迁徙
个人简介
HONORS:
Award of Distinguished Thesis, Tien-Te Lee Biomedical Foundation, Taiwan (2008)
Ta-Yu Wu Memorial Award, National Science Council, Taiwan (2008)
Dr. Ta-Cheng Tung Memorial Award for Basic Cancer Research, Chinese Oncology Society, Taiwan (2009)
First prize of Distinguished Thesis, Taipei Veterans General Hospital (2009, 2011)
Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan (2011)
Award for Junior Research Investigators, Academia Sinica (2011)
RESEARCH INTERESTS:
Epithelial-mesenchymal transition (EMT) is one of the major mechanisms of cancer metastasis. However, the pleiotropic effects of EMT regulators in additional to the promotion of cellular migration have been investigated limitedly. We recently discover several novel functions of the EMT regulators during head and neck cancer progression. First, we confirm the direct regulation of the stemness-related gene BMI1 by the EMT regulator Twist1. Twist1 and BMI1 are mutually essential in promoting EMT and tumor-initiating capability. Second, we identify the mechanism of Twist1-induced motility through repressing microRNA let-7i and activating RAC1. Third, we show the induction of chromosomal instability by BMI1 through upregulating Aurora A expression. Fourth, we find a pathway of Snail-induced cisplatin resistance through induction of ERCC1 expression. In the future, we will keep focusing on the pleiotropic effects of EMT regulators during cancer metastasis and confirm their clinical significance.
Award of Distinguished Thesis, Tien-Te Lee Biomedical Foundation, Taiwan (2008)
Ta-Yu Wu Memorial Award, National Science Council, Taiwan (2008)
Dr. Ta-Cheng Tung Memorial Award for Basic Cancer Research, Chinese Oncology Society, Taiwan (2009)
First prize of Distinguished Thesis, Taipei Veterans General Hospital (2009, 2011)
Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan (2011)
Award for Junior Research Investigators, Academia Sinica (2011)
RESEARCH INTERESTS:
Epithelial-mesenchymal transition (EMT) is one of the major mechanisms of cancer metastasis. However, the pleiotropic effects of EMT regulators in additional to the promotion of cellular migration have been investigated limitedly. We recently discover several novel functions of the EMT regulators during head and neck cancer progression. First, we confirm the direct regulation of the stemness-related gene BMI1 by the EMT regulator Twist1. Twist1 and BMI1 are mutually essential in promoting EMT and tumor-initiating capability. Second, we identify the mechanism of Twist1-induced motility through repressing microRNA let-7i and activating RAC1. Third, we show the induction of chromosomal instability by BMI1 through upregulating Aurora A expression. Fourth, we find a pathway of Snail-induced cisplatin resistance through induction of ERCC1 expression. In the future, we will keep focusing on the pleiotropic effects of EMT regulators during cancer metastasis and confirm their clinical significance.
研究兴趣
论文共 312 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jameel Muzaffar,Kedar Kirtane, Rebecca Redman,Muh-Hwa Yang,Tae Min Kim,Stephen Liu,Ryan Lynch,Julie Brahmer, Patricia LoRusso,Brian Henick,Sung-bae Kim,Yin-Hsun Feng,
Cancer Researchno. 7_Supplement (2024)
CANCER SCIENCEno. 1 (2024): 270-282
BMC Cancerno. 1 (2024): 1-11
npj Virusesno. 1 (2024): 1-10
Ming-Yu Chou, Wen-Chi Wu,Pen-Yuan Chu,Shyh-Kuan Tai,Peter Mu-Hsin Chang,Tsung-Lun Lee,Tien-Hua Chen,Muh-Hwa Yang
In vivo (Athens, Greece)no. 4 (2024): 1891-1899
Tsai-Tsen Liao, Yu-Hsien Chen, Zih-Yu Li, An-Ching Hsiao, Ya-Li Huang, Ruo-Xin Hao,Shyh-Kuan Tai,Pen-Yuan Chu,Jing-Wen Shih, Hsing-Jien Kung,Muh-Hwa Yang
Cancer immunology research (2024)
Cancer Researchno. 6_Supplement (2024): 7612-7612
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn