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The overall interest of my laboratory is to identify the underlying causes of neurodegenerative diseases such as Alzheimer's disease. Once causes or experimental endpoints are determined, then strategies to find chemicals which can ameliorate pathophysiological events can be devised. In general, we are working to create transgenic animals and validate them as models of human disease.
Our specific approach has been to study the function of apolipoprotein-E (apoE) which Roses and colleagues found to a susceptibility factor for the presence of AD. Currently, our data are pointing to a relationship between apoE and oxidative stress where apoE appears to modulate nitric oxide production in a species specific manner. To further test this idea, we have created transgenic mice expressing the entire human NOS2 gene which will now be tested in various models of neurodegeneration and inflammation. Similarly, we are developing transgenic animals which express the human TAU gene. When properly stressed, these TAU-transgenic animals may display the neurofibrillary tangle pathology which is associated with neurodegeneration in a wide variety of neurological diseases.
Our specific approach has been to study the function of apolipoprotein-E (apoE) which Roses and colleagues found to a susceptibility factor for the presence of AD. Currently, our data are pointing to a relationship between apoE and oxidative stress where apoE appears to modulate nitric oxide production in a species specific manner. To further test this idea, we have created transgenic mice expressing the entire human NOS2 gene which will now be tested in various models of neurodegeneration and inflammation. Similarly, we are developing transgenic animals which express the human TAU gene. When properly stressed, these TAU-transgenic animals may display the neurofibrillary tangle pathology which is associated with neurodegeneration in a wide variety of neurological diseases.
Research Interests
Papers共 271 篇Author StatisticsCo-AuthorSimilar Experts
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Anupriya Agarwal,Ryan J. MacKenzie,Raffaella Pippa,Christopher A. Eide, Jessica Oddo,Jeffrey W. Tyner,Rosalie Sears,Michael P. Vitek,María D. Odero,Dale J. Christensen, Brian J. Druker
crossref(2023)
Pharmaceuticsno. 4 (2023): 1086-1086
crossref(2023)
crossref(2023)
crossref(2023)
Lisa A. Ridnour,Robert Y.S. Cheng,William F. Heinz,Milind Pore,Ana L. Gonzalez,Elise L. Femino, Rebecca Moffat,Adelaide L. Wink,Fatima Imtiaz, Leandro Coutinho,Donna Butcher,Elijah F. Edmondson,
bioRxiv the preprint server for biology (2023)
Bo Wang,Feng-Wan Zhang,Wei-Xiao Wang,Yan-Yan Zhao,Su-Yue Sun, Jin-Hong Yu,Michael P. Vitek, George F. Li, Rui Ma,Shiwei Wang,Zhiliang Hu,Wei Chen
Katherine I. Swenson-Fields,Christopher J. Ward, Micaila E. Lopez, Shaneann Fross, Anna L. Heimes Dillon,James D. Meisenheimer, Adib J. Rabbani, Emily Wedlock, Malay K. Basu,Kyle P. Jansson,Peter S. Rowe,Jason R. Stubbs,
Frontiers in Molecular Biosciences (2022)
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