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个人简介
My research interest is the role of neuronal guidance cues in inflammation and vascular biology. The ligands and receptors of the Neuronal Guidance Cues (NGCs) are emerging as significant regulators of inflammation. As a post-doc in the in the lab of Prof. K.J. Moore at Harvard Medical School and New York University I received an excellent training in atherosclerosis biology and gained the foundation for my vast interest and knowledge on neuronal guidance cues. A personal fellowship from the American Heart Association allowed me to demonstrate that the NGC netrin-1 is highly expressed and secreted by macrophages and promotes atherosclerosis by inhibiting the emigration of macrophages from the plaques. A paper describing this work, that was published in Nature immunology (van Gils et al. Nat Immunol. 2012), received international interest and was awarded the Vascular Biology Award in 2012. In subsequent studies, we provided evidence that several NGCs may also be involved in the adhesion of leukocytes to endothelial cells and the subsequent migration of leukocytes into the subendothelial space.
As a PI, I obtained research funding from the Dutch Heart Foundation, Rembrandt Institute on Cardiovascular Science and European Research Area Network on Cardiovascular Diseases. With these I have established my own research line on NGCs and atherosclerosis in the Einthoven Laboratory. My goal is to acquire a deeper insight into the role of NGCs in cardiovascular diseases and take the next step towards translation and assess the clinical relevance in patients with cardiovascular diseases.
研究兴趣
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VACCINEno. 7 (2024): 1478-1486
The EMBO journalno. 7 (2024): 1135-1163
Frontiers in immunology (2024): 1390022-1390022
Mitch Brinkkemper,Meliawati Poniman,Esther Siteur-van Rijnstra, Widad Ait Iddouch,Tom P.L. Bijl,Denise Guerra,Khadija Tejjani,Marloes Grobben,Farien Bhoelan, Denzel Bemelman, Ronald Kempers,Marit J. van Gils,
Virus research (2024): 199308-199308
The Journal of infectious diseases (2024)
Anne L Timmerman, Lisanne Commandeur,Martin Deijs, Maarten G J M Burggraaff,A H Ayesha Lavell,Karlijn van der Straten,Khadija Tejjani,Jacqueline van Rijswijk,Marit J van Gils,Jonne J Sikkens,Marije K Bomers,Lia van der Hoek
Virusesno. 1 (2024): 99
ANTIVIRAL RESEARCH (2024): 105788-105788
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