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个人简介
Immunological tolerance is the balance between immunity to infection and autoimmunity, dysregulation of which can result in severe immunological pathologies. Our laboratory investigates the molecular regulation of (patho-) physiological immune responses with a particular focus on the metabolic programming of lymphocytes. Over the last decade, it became clear that ‘immunometabolism’ not only provides chemical energy and building blocks for the clonal expansion and effector function of lymphocytes, but also governs the epigenetic programming of immune cells. Thus, a better understanding of the metabolic-epigenetic regulatory circuits in immune cells promises new therapeutic avenues to treat immune-related pathologies, such as infection, cancer or autoimmunity.
Unlike most other tissues, immune cells are not sessile but patrol and populate all organs in the body. To cope with the varying metabolic conditions in different (non-lymphoid) tissues, immune cells are equipped with an extensive enzymatic repertoire. This versatility of leukocytes and the notion that cellular metabolism is intrinsically linked to the outcome of complex immune responses established ‘immunometabolism’ as an independent and interdisciplinary research field. A plethora of catabolic and anaplerotic reactions are directly linked to signal transduction, epigenetic modifications and the control of gene expression. Thus, the interrelation of cellular metabolism, signaling and epigenetic imprinting constitutes an intra-cellular network that controls the fate and function of immune cells.
We study various aspects of this network in the immune system across scales by combining functional studies in transgenic animal models with (single-cell) transcriptomic, metabolomic and epigenetic analyses. A better understanding how metabolism controls the complex functions of the immune system will not only provide novel therapeutic concepts to treat inflammatory and autoimmune diseases but will also help to exploit the inherent capacity of leukocytes to combat pathogens and cancer.
研究兴趣
论文共 92 篇作者统计合作学者相似作者
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Yin-Hu Wang, Wenyi Li, Maxwell McDermott,Ga-Yeon Son,George Maiti,Fang Zhou,Anthony Tao,Dimitrius Raphael,Andre L. Moreira, Boheng Shen,Martin Vaeth,Bettina Nadorp,
bioRxiv the preprint server for biology (2024)
Maria Batliner,Fabian Schumacher,Dominik Wigger,Wolfgang Vivas, Agata Prell, Ingo Fohmann, Tobias Köhler, Rebekka Schempp, Angela Riedel,Martin Vaeth,Agnes Fekete,Burkhard Kleuser,
H. Wu, X. Zhao, A. Oener, Hochrein,M. Eckstein, K. Knoepper,A. Mansilla,R. Doucet-Ladeveze,B. Ghesquiere,S. Theurich,J. Dudek,G. Gasteiger,
EUROPEAN JOURNAL OF IMMUNOLOGY (2023): 51-51
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Cell reportsno. 6 (2023): 112583-112583
European journal of pharmacology (2023): 175552-175552
bioRxiv (Cold Spring Harbor Laboratory) (2023)
ISCIENCEno. 3 (2023): 106234-106234
Cell metabolismno. 4 (2022): 516-532.e11
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