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Areas of investigation include: molecular and cellular physiology of glutamatergic transmission, mechanisms of delayed neurodegeneration induced by global ischemia, neuroprotection after ischemia or other insult and gap junction mediated intercellular communication.
Glutamatergic transmission is the primary mode of excitation in the nervous system. Modifications of synaptic efficacy underlie development and learning and also play important roles in disease processes. NMDA receptors, one class responding to glutamate, mediate forms of long term potentiation and depression, which can underlie memory. Protein kinases and phosphatases modify single channel properties and trafficking, i.e., movement out from the cell body, dendritic synthesis, insertion into the surface membrane, removal, and recycling or degradation. Delayed neuronal death in the hippocampal CA1 following global ischemia and in CA3 following kainate induced status epilepticus results from down regulation of GluR2, the AMPA receptor subunit that limits calcium permeability of these receptors. Increased Ca2+ influx in response to endogenous glutamate then triggers cell death by Ca2+ overload. GluR2 downregulation is mediated by REST(RE-1 silencing transcription factor), which is upregulated after ischemia. In ischemic preconditioning a brief period of ischemia leads to tolerance of a longer lasting and otherwise injurious ischemic episode. We are identifying changes in gene expression responsible for ischemic tolerance after preconditioning.
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 11 (2024): e2400272121-e2400272121
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 25 (2023)
Neurobiology of disease (2023): 106078-106078
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#Papers: 334
#Citation: 37493
H-Index: 109
G-Index: 187
Sociability: 7
Diversity: 3
Activity: 11
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