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Immune cells zip through our bodies at high speeds to fight off infections and diseases. The Sixt group works at the interface of cell biology and immunology to investigate how cells are able to migrate through tissues.
Most cells in our bodies are stationary, forming solid tissues and encapsulated organs. One exception are leukocytes, immune cells essential for both the innate and adaptive immune responses to infections. Leukocytes migrate with extraordinary speed and are used by the Sixt group as a model to study cell migration. The group works at the interface of cell biology, immunology, and biophysics, and aims to identify basic mechanistic principles that are equally important for developmental processes and cancer cells. One research focus is how the cell’s internal skeleton generates and transduces the force to change shape, move the cell body and interact with other cells. The group also investigates how cells navigate along guidance cues, specifically how they orient their polarity axis in response to chemotactic gradients. In their work, the members of the Sixt group combine genetics, pharmacology, micro-engineering, surface chemistry, and advanced imaging approaches, as well as in vivo imaging techniques.
Most cells in our bodies are stationary, forming solid tissues and encapsulated organs. One exception are leukocytes, immune cells essential for both the innate and adaptive immune responses to infections. Leukocytes migrate with extraordinary speed and are used by the Sixt group as a model to study cell migration. The group works at the interface of cell biology, immunology, and biophysics, and aims to identify basic mechanistic principles that are equally important for developmental processes and cancer cells. One research focus is how the cell’s internal skeleton generates and transduces the force to change shape, move the cell body and interact with other cells. The group also investigates how cells navigate along guidance cues, specifically how they orient their polarity axis in response to chemotactic gradients. In their work, the members of the Sixt group combine genetics, pharmacology, micro-engineering, surface chemistry, and advanced imaging approaches, as well as in vivo imaging techniques.
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论文共 174 篇作者统计合作学者相似作者
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Nature immunologyno. 7 (2024): 1131-1132
Patricia Reis-Rodrigues,Nikola Canigova, Mario J. Avellaneda, Florian Gaertner, Kari Vaahtomeri,Michael Riedl, Jack Merrin, Robert Hauschild,Yoshinori Fukui, Alba Juanes Garcia,Michael Sixt
biorxiv(2024)
Journal of Allergy and Clinical Immunology (2024)
Mario J. Avellaneda,Michael Sixt
Cell Chemical Biologyno. 7 (2024): 1242-1243
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Frontiers in Cell and Developmental Biology (2023): 1287420-1287420
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