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个人简介
Sadelain and his team study gene transfer in hematopoietic stem cells and T cells, the regulation of transgene expression, the biology of chimeric antigen receptors, and therapeutic strategies to enhance immunity against cancer. Sadelain is a recognized leader in the conceptualization and design of synthetic receptors for antigen, which he named chimeric antigen receptors (CARs). T cells can be engineered to express a CAR to acquire the ability to recognize and destroy cancer cells. Sadelain has referred to CAR T cells as a “living drug.” A CAR typically comprises an antibody fragment (scFv) to recognize the cancer and a modular signaling domain to activate the T cell and promote T cell multiplication and persistence. CAR T cells are made by extracting a cancer patient’s T cells, inserting a CAR into the cell using a vector such as a gamma-retroviral or lentiviral vector, and then re-infusing the cells. Sadelain's current research makes use of genome editing, which he showed enhances CAR T cells when the CAR is expressed from the TRAC locus.
研究兴趣
论文共 552 篇作者统计合作学者相似作者
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#Papers: 561
#Citation: 45354
H-Index: 92
G-Index: 209
Sociability: 8
Diversity: 0
Activity: 3
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