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The long-term objective of my program since 1976 has been to develop and characterize an experimentally tractable human mammary epithelial cell (HMEC) culture system for use in a wide variety of studies on normal human cell biology, aging, and carcinogenesis. Our aim has been to understand normal HMEC processes, and how these processes may be altered during immortal and malignant transformation, and during aging. We believe that understanding normal healthy biology is necessary for clear understanding of what constitutes abnormal processes. Our desire to facilitate widespread use of human epithelial cells for molecular and cellular biology studies has led us to develop an HMEC system that is relatively easy to use, can provide large quantities of standardized cell populations, and is well-characterized. Ongoing collaborative studies assessing the effects of cell-cell and cell-ECM components aim to improve the ability of this in vitro culture system to accurately reflect in vivo biology.
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Papers共 247 篇Author StatisticsCo-AuthorSimilar Experts
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Robert Lowe, Marita G. Overhoff,Sreeram V. Ramagopalan,James C. Garbe,James Koh,Martha R. Stampfer, David H. Beach,Vardhman K. Rakyan,Cleo L. Bishop
GENOME BIOLOGYno. 1 (2024)
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