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个人简介
Sousa MM heads the Nerve Regeneration Group at the IBMC/i3S. The Nerve Regeneration group is interested in characterizing pathways that control axon growth during development, and axon degeneration and regeneration following injury and disease. We have a special focus on the study of axonal cytoskeleton organization and dynamics, and axonal trafficking. Research in our group has currently the following main objectives: i)Understand the biogenesis and function of axonal actin rings; ii) Understand cytoskeleton dynamics in the growth cone during axon formation and regeneration; iii) Dissect the central-peripheral polarity in dorsal root ganglia neurons; iv) Understand cytoskeleton alterations occurring during neurodegeneration. Our work relies on in vitro systems (neuronal cell cultures) and in vivo models (mouse and rat), including the model of spinal cord injury and models of rare neurodegenerative disorders. The above cellular and in vivo models combined with cell biology, genetic strategies, biochemical approaches, and state-of-the-art microscopy allow the identification of mechanisms regulating axon growth, degeneration and regeneration.
研究兴趣
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Frontiers in Pediatrics (2023): 1251053-1251053
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